Archivio · Preprint · 2026
TMS-evoked phosphenes and oculomotor responses in visual-snow syndrome
Roman Akinshin, Dinara Shankhoeva, Dmitry Gribanov, Artemiy Berkmush-Antipova, Polina Meschanina, Tomilina I, Elizaveta Ostrovskaia, Sergei Gostilovich, Nikolay Syrov, Anh Huy Phan, Lebedev M
medRxiv
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Abstract originale
Testo degli autori, riprodotto perché la licenza lo consente (Testo completo ripubblicabile, cc-by).
Abstract Visual Snow Syndrome (VSS) is a neurological condition characterized by continuous visual disturbances resembling television static across the visual field. Despite its significant impact on quality of life, objective assessment methods remain limited, with diagnosis relying primarily on subjective patient reports. Current understanding of VSS pathophysiology suggests cortical hyperexcitability, but precise mechanisms remain unclear. Here we developed an integrated protocol combining transcranial magnetic stimulation (TMS)-evoked phosphene mapping with high-resolution eye-tracking analysis. Four VSS patients diagnosed and eight age-matched healthy controls participated. Using individualized MRI-guided navigation, TMS pulses were delivered to occipital cortex regions. After each pulse, participants indicated perceived phosphene locations on a digital tablet. Eye movements were recorded continuously using a Tobii eye-tracker at 120 Hz. Participants completed prosaccade tasks to assess basic oculomotor function, and post-TMS oculomotor responses were analyzed. The VSS participants had significantly altered phosphene perception patterns with more diffuse spatial distribution compared to the controls’ more centralized and concentrated patterns. Prosaccade latencies were significantly shorter in VSS participants compared to healthy controls. Post-TMS oculomotor responses showed markedly reduced saccadic velocity in the VSS patients versus controls. Thus, the combination of phosphene mapping and eye-tracking analysis provides an efficient tool for VSS assessment and paves the way to uncovering its underlying pathophysiology.
Dati bibliografici
- Tipo
- Preprint
- Revisione paritaria
- Revisione non verificata
- Accesso
- Accesso aperto
- Riutilizzo
- Testo completo ripubblicabile (cc-by)
- OpenAlex
- W7128438613
Autori
- Roman Akinshinautore di riferimentoSkolkovo Institute of Science and Technology
- Dinara ShankhoevaSechenov University
- Dmitry GribanovSkolkovo Institute of Science and Technology
- Artemiy Berkmush-AntipovaORCID 0000-0001-9350-0845Immanuel Kant Baltic Federal University
- Polina MeschaninaSechenov University
- Tomilina I
- Elizaveta OstrovskaiaSechenov University
- Sergei GostilovichORCID 0000-0002-1704-0717Skolkovo Institute of Science and Technology
- Nikolay SyrovORCID 0000-0002-8253-9426Skolkovo Institute of Science and Technology
- Anh Huy PhanORCID 0000-0002-5509-7773Skolkovo Institute of Science and Technology
- Lebedev M
Come citare questo lavoro
Roman Akinshin, Dinara Shankhoeva, Dmitry Gribanov, et al.. TMS-evoked phosphenes and oculomotor responses in visual-snow syndrome. medRxiv. 2026. doi:10.64898/2026.02.05.26344851
Cita sempre il lavoro originale, non questa pagina: l'archivio è un indice, gli autori sono altri.
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